Germliner™ Platform

Fully Human Antibody Discovery

Epitope-Guided Antibody Humanization

>>> Antibody Optimization


Antibody Optimization

The variable regions of the antibody heavy and light chains in the AvantGen's library are constructed with two separate and interchangeable modules. Each module in an existing antibody can be switched easily with a mini-library of the corresponding modules.

If further optimization of any Germliner™ antibody is desired, a smaller focused library can be created rapidly and screened. For example, antibodies can be selected for higher affinity or other binding properties, such as blocking activity, cross-reactivity or lack of cross-reactivity to related members of the protein family of interest.

This process has been integrated effectively with library construction and screening, resulting in a rapid pathway from an existing antibody to a fully human antibody with desired pharmacological properties.