Technologies

Germliner™ Platform

Fully Human Antibody Discovery

Epitope-Guided Antibody Humanization

Antibody Optimization

 
Germliner™ Platform

AvantGen’s Germliner™ antibodies are fully synthetic human antibodies with human antibody germline frameworks and designed CDRs. Since germline antibody framework sequences are highly tolerated between individuals, Germliner™ antibodies minimize the likelihood of eliciting neutralizing anti-antibody reactions in humans, yet they exhibit high affinity and specificity to targets of interest ... more

Fully Human Antibody Discovery

Based on the design of Germliner™ antibodies, AvantGen has constructed a large human Fab library displayed by yeast cells. Novel human antibodies with high affinity and specificity can be discovered in a matter of weeks ... more

Epitope-Guided Antibody Humanization

AvantGen has developed a rapid technology to humanize non-human monoclonal antibodies. The humanized antibodies retain full activity of the non-human antibodies, while eliminating most of the non-human sequences. Only CDR-H3 of the non-human antibody is retained. ... more

Antibody Optimization

AvantGen’s technology platform allows rapid optimization of existing monoclonal antibodies to produce new versions of fully human antibodies with desired pharmacological properties ... more